Ornements des imprimeurs de l\u27ancien temps sur le web (Les)

Colloque: Vers une nouvelle érudition : numérisation et recherche en histoire du livre, Rencontres Jacques Cartier, Lyon, décembre 1999

Les récits de voyage illustrés à l’ère numérique / Illustrated Travel Accounts in the Digital Age

Livre de l'exposition organisée à l'Université de Lausanne dans le cadre de la 11e Conférence internationale de l’IAWIS/AIERTI |11th International IAWIS/AIERTI Conference consacrée à la reproduction des images et des textes | Images and texts reproduced. L’équipe VIATICALPES et la Bibliothèque cantonale et universitaire de Lausanne proposent un parcourt de découverte allant du livre ancien à sa diffusion à l’ère numérique. Université de Lausanne, Amphimax, 10-14 juillet 201

Vers une nouvelle érudition : numérisation et recherche en histoire du livre

En décembre 1999, à l\u27Enssib, s’est déroulé le colloque "Vers une nouvelle érudition : numérisation et recherche en histoire du livre", organisé dans le cadre des 12e Entretiens du Centre Jacques Cartier sous la responsabilité de Dominique Varry (enssib), Annie Charon (école nationale des chartes) et Guylaine Baudry (Université de Montréal)

The Superoanterior Fasciculus (SAF): A Novel White Matter Pathway in the Human Brain?

Fiber tractography (FT) using diffusion magnetic resonance imaging (dMRI) is widely used for investigating microstructural properties of white matter (WM) fiber-bundles and for mapping structural connections of the human brain. While studying the architectural configuration of the brain’s circuitry with FT is not without controversy, recent progress in acquisition, processing, modeling, analysis, and visualization of dMRI data pushes forward the reliability in reconstructing WM pathways. Despite being aware of the well-known pitfalls in analyzing dMRI data and several other limitations of FT discussed in recent literature, we present the superoanterior fasciculus (SAF), a novel bilateral fiber tract in the frontal region of the human brain that—to the best of our knowledge—has not been documented. The SAF has a similar shape to the anterior part of the cingulum bundle, but it is located more frontally. To minimize the possibility that these FT findings are based on acquisition or processing artifacts, different dMRI data sets and processing pipelines have been used to describe the SAF. Furthermore, we evaluated the configuration of the SAF with complementary methods, such as polarized light imaging (PLI) and human brain dissections. The FT results of the SAF demonstrate a long pathway, consistent across individuals, while the human dissections indicate fiber pathways connecting the postero-dorsal with the antero-dorsal cortices of the frontal lobe

Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia, A double-blind, randomised, placebo-controlled trial

Rationale: Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia. Methods: In this multicenter, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with Covid-19 pneumonia were randomised to receive 1 g of methylprednisolone intravenously for 3 consecutive days or placebo in addition to standard dexamethasone. The primary outcome was the duration of the patient hospitalisation, calculated as the time interval between randomisation and hospital discharge without the need of supplementary oxygen. The key secondary outcomes were survival free from invasive ventilation with orotracheal intubation and overall survival. Results: Overall, 112 of 151 (75.4%) patients in the pulse methylprednisolone arm and 111 of 150 (75.2%) in the placebo arm were discharged from hospital without oxygen within 30 days from randomisation. Median time to discharge was similar in both groups [15 days (95% confidence interval (CI), 13.0 to 17.0) and 16 days (95%CI, 13.8 to 18.2); hazard ratio (HR), 0.92; 95% CI 0.71-1.20; p=0.528]. No significant differences between pulse methylprednisolone and placebo arms were observed in terms of admission to Intensive Care Unit with orotracheal intubation or death (20.0% versus 16.1%; HR, 1.26; 95%CI, 0.74-2.16; p=0.176), or overall mortality (10.0% versus 12.2%; HR, 0.83; 95%CI, 0.42-1.64; p=0.584). Serious adverse events occurred with similar frequency in the two groups. Conclusions: Methylprenisolone pulse therapy added to dexamethasone was not of benefit in patients with COVID-19 pneumonia. Message of the study: Pulse glucocorticoid therapy is used for severe and/or life threatening immuno-inflammatory diseases. The addition of pulse glucocorticoid therapy to the standard low dose of dexamethasone scheme was not of benefit in patients with COVID-19 pneumonia

Impacto dos procedimentos cirúrgicos múltiplos concomitantes no risco de infecção de sítio cirúrgico

Exportado OPUSMade available in DSpace on 2019-08-12T07:00:09Z (GMT). No. of bitstreams: 1 disserta__o_silvio_augusto_corsini_menicucci.pdf: 524805 bytes, checksum: e42c327e3cc2f5beb7420c12a4b9959a (MD5) Previous issue date: 3Trata-se de uma coorte histórica aberta em que foram acompanhados 190.443 pacientes cirúrgicos para estudo da infecção de sítio cirúrgico (ISC) e seus fatores de risco. Os fatores de risco potenciais para ISC estudados foram: o grau de contaminação da ferida cirúrgica de acordo com o National Research Council, o risco cirúrgico anestésico de acordo com os critérios da American Society of Anesthesiologists, a duração da cirurgia em minutos maior que o percentil 75 da população do estudo, o número de procedimentos cirúrgicos simultâneos aos quais o paciente foi submetido, o tipo de cirurgia (eletiva/urgência/trauma) e o contato telefônico pós-alta. As análises uni e multivariada foram feitas utilizando a técnica de regressão logística. A adequação do modelo foi avaliada pelo teste Hosmer-Lemeshow. Utilizou-se nível de significância de 0,05 e intervalo de confiança de 95%. A maior parte dos pacientes foi submetida a apenas um procedimento cirúrgico (98%) e apresentava o risco cirúrgico anestésico de acordo com a American Society of Anesthesiologists (ASA) no seu menor nível, 1 (82,5%). As cirurgias eletivas corresponderam a 65,5% dos procedimentos sendo aquelas com ferida potencialmente contaminada as mais comuns (61,2%) seguidas de cirurgias limpas (31,2%) e a ISC ocorreu em 3,9% dos casos. A vigilância após a alta de alcançou 57,4% dos pacientes. Ao se efetuar a análise univariada todos os fatores de risco potenciais mostraram associação com a ISC. A análise multivariada manteve como fator de risco o tempo de cirurgia acima de 100 minutos (OR 1,70 e p=0,001), o número de procedimentos cirúrgicos aos quais o paciente foi submetido: 2 (OR 1,43 e p=0,001) e 3 ou 4 (OR 1,91 e p=0,049), o potencial de contaminação da ferida cirúrgica: potencialmente contaminada (OR 1,70 e p=0,001), contaminada (OR 2,13 e p=0,001) e infectada (OR 2,81 e p=0,001) e a classificação ASA: 2 (OR 1,36 e p=0,001), 3 (OR 3,20 e p=0,001) e 4 ou 5 (OR 2,50 e p=0,001) e o contato telefônico pós-alta (OR 2,19 e p=0,001) como fatores de risco para a infecção de sítio cirúrgico.It is an opened historical cohort where 190.443 surgical patients were supported in order to study the surgical site infection (SSI) and its risk factors. The studied potential risk factors for SSI were: the degree of contamination of the surgical wound according to the National Research Council, the anesthetic surgical risk according to the American Society of Anesthesiologists criteria, the length in minutes of the surgery longer than the percentile 75 of the study population, the number of simultaneous surgical procedures which the patient was submitted, the type of surgery (elective/urgency/trauma) and after discharge contact. The univariated and multivariated analyses were accomplished according to the technique of logistic regression. The adequacy of the model was evaluated by the Hosmer-Lemeshow test. It was used a significance level of 0,05 and confidence interval of 95%. Most of the patients was submitted to only one surgical procedure (98%) and demonstrated the anesthetic surgical risk according to the American Society of Anesthesiologists (ASA) in its lower level, 1 (82,5%). The elective surgeries corresponded to 65,5% of the procedures being those with potentially contaminated wound the most common (61,2%) followed by clean surgeries (31,2%) and the SSI occurred in 3,9% of the cases. When performing the univariated analysis, all the potential risk factors demonstrated connection with the ISS. The multivariated analysis sustained as risk factor the time of the surgery over 100 minutes (OR 1,70 and p=0,001 ), the number of surgical procedures which the patient was submitted: 2 (OR 1,43 and p=0,001) and 3 or 4 (OR 1,91 and p=0,049), the potential of contamination of the surgical wound: potentially contaminated (OR 1,70 and p=0,001), contaminated (OR 2,13 and p=0,001) and infected (OR 2,81 and p=0,001) and the ASA classification: 2 (OR 1,36 and p=0,001), 3 (OR 3,20 and p= 0,001) and 4 or 5 (OR 2,50 and p=0,001) and after discharge contact (OR 2,19 and p=0,001) as risk factors for the surgical site infection